Thermogenic synergism between ephedrine and caffeine in healthy volunteers: A double-blind, placebo-controlled study
Identifieur interne : 001102 ( Main/Exploration ); précédent : 001101; suivant : 001103Thermogenic synergism between ephedrine and caffeine in healthy volunteers: A double-blind, placebo-controlled study
Auteurs : Arne Astrup [Danemark] ; S Ren Toubro [Danemark] ; Stephen Cannon [Danemark] ; Pia Hein [Danemark] ; Joop Madsen [Danemark]Source :
- Metabolism [ 0026-0495 ] ; 1991.
Abstract
Animal and human studies have suggested a thermogenic synergism between ephedrine (E), a β-agonist, and caffeine (C), an adenosine antagonist, which may be suitable for the treatment of obesity. To study this phenomenon, the thermogenic effect of single doses of oral placebo, E 10 mg, E 20 mg, C 100 mg, and C 200 mg were compared with the effects of three different combinations of E + C, 10 mg200 mg, 20 mg100mg, and 20 mg200 mg, measured by indirect calorimetry in six healthy, lean subjects. The thermogenic effect after E + C 20 mg200 mg was larger than that of any of the other combinations. In this dose ratio, ephedrine and caffeine exerted a supra-additive synergism whereas the thermogenic effects of the other two combinations were only additive. The 3-hour postintake increase in systolic blood pressure after all three combinations averaged 5 to 7 mm Hg more than placebo (P < .01), which exceeded the predicted additive effect fivefold to sevenfold. Diastolic blood pressure was not increased by E + C 20 mg200 mg, whereas the other two combinations increased it by approximately 4 mm Hg more than placebo. E + C 20 mg100 mg and 20 mg200 mg increased heart rate more than placebo, while E + C 10 mg200 mg had no effect on heart rate. As expected, all combinations increased plasma glucose, insulin, and C-peptide from their ephedrine content. No significant effects of the combinations were found on plasma lactate, glycerol, nonesterified fatty acids (NEFA), triglyceride, potassium, or sodium. The combination of E + C 20 mg200 mg has a favorable thermogenic effect (30 kcal3 h), with no marked effect on mean blood pressure and heart rate. This combination may be useful in the treatment of obesity.
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DOI: 10.1016/0026-0495(91)90117-F
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xml:lang="en">Animal and human studies have suggested a thermogenic synergism between ephedrine (E), a β-agonist, and caffeine (C), an adenosine antagonist, which may be suitable for the treatment of obesity. To study this phenomenon, the thermogenic effect of single doses of oral placebo, E 10 mg, E 20 mg, C 100 mg, and C 200 mg were compared with the effects of three different combinations of E + C, 10 mg200 mg, 20 mg100mg, and 20 mg200 mg, measured by indirect calorimetry in six healthy, lean subjects. The thermogenic effect after E + C 20 mg200 mg was larger than that of any of the other combinations. In this dose ratio, ephedrine and caffeine exerted a supra-additive synergism whereas the thermogenic effects of the other two combinations were only additive. The 3-hour postintake increase in systolic blood pressure after all three combinations averaged 5 to 7 mm Hg more than placebo (P < .01), which exceeded the predicted additive effect fivefold to sevenfold. Diastolic blood pressure was not increased by E + C 20 mg200 mg, whereas the other two combinations increased it by approximately 4 mm Hg more than placebo. E + C 20 mg100 mg and 20 mg200 mg increased heart rate more than placebo, while E + C 10 mg200 mg had no effect on heart rate. As expected, all combinations increased plasma glucose, insulin, and C-peptide from their ephedrine content. No significant effects of the combinations were found on plasma lactate, glycerol, nonesterified fatty acids (NEFA), triglyceride, potassium, or sodium. The combination of E + C 20 mg200 mg has a favorable thermogenic effect (30 kcal3 h), with no marked effect on mean blood pressure and heart rate. This combination may be useful in the treatment of obesity.</div></front></TEI><affiliations><list><country><li>Danemark</li></country><region><li>Hovedstaden</li></region><settlement><li>Copenhague</li></settlement></list><tree><country name="Danemark"><region name="Hovedstaden"><name sortKey="Astrup, Arne" sort="Astrup, Arne" uniqKey="Astrup A" first="Arne" last="Astrup">Arne Astrup</name></region><name sortKey="Cannon, Stephen" sort="Cannon, Stephen" uniqKey="Cannon S" first="Stephen" last="Cannon">Stephen Cannon</name><name sortKey="Hein, Pia" sort="Hein, Pia" uniqKey="Hein P" first="Pia" last="Hein">Pia Hein</name><name sortKey="Madsen, Joop" sort="Madsen, Joop" uniqKey="Madsen J" first="Joop" last="Madsen">Joop Madsen</name><name sortKey="Toubro, S Ren" sort="Toubro, S Ren" uniqKey="Toubro S" first="S Ren" last="Toubro">S Ren Toubro</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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